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In the current HepG2 cell model, in which prolonged exposure is not feasible, the use of relatively high QI concentrations in a short timeframe allows for the identification of underlying mechanisms and pathways, as has been done previously in similar studies with hepatic toxicants (Tafazoli and OBrien, 2009

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6 Potential limitations of polyphenols in neuroinflammation and neurodegeneration Polyphenols, while showing potential in the treatment of neuroinflammation, encounter limitations such as low bioavailability, instability in the gastrointestinal tract, and fast metabolism, which minimize their therapeutic effectiveness

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