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The major histocompatibility complex (MHC) region at 6p21, which express human leukocyte antigens (HLAs), was the first identified gene locus

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Numerous studies have revealed that aberrant pathways, including transforming growth factor-/Smad (TGF-/Smad), Wnt/-catenin, inhibition of kappa B (IB)/nuclear factor kappa B (NF-B), and Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2), are involved in renal fibrosis [23, 26, 27]