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Polymorphisms of these genes or associated regulatory sequences, or copy number variations (CNV) may contribute to a reduction in UGT activity or indeed loss of function and, therefore, reduce paracetamol glucuronidation

Design, synthesis, and evaluation of diazeniumdiolate-based DNA cross-linking agents activatable by glutathione S-transferase

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parameters like skin brightness(L*), blue-yellow coloration (b) and individual tipology angle were quantified through ChromaMeter CR400 Minolta, while images were drawn through a UV-scan and Fotofinder dermoscope ver.2.0 The results summarized in Figure 4 show that Kalilight cream increases skin lightening better than the cream with benchmark actives, while the UV scan and pictures in figure 5 and 6 prove its significant performances in decreasing the intensity of skin spots.

Statements Author contributions YL: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Supervision, Writing original draft, Writing review & editing