Research into these mechanisms is still evolving, and microdose-level effects have not been specifically studied in clinical trials, but the biological rationale is sound: activating two complementary hormonal pathways at low levels may produce a broader metabolic nudge than activating one pathway alone
Interaction with GABA A R 2 subunit may also activate CB (Tretter et al., 2008)
It is entirely normal to wonder if medication is truly necessary when you have no symptoms, but medical experts strongly advise that lifelong L-carnitine supplementation is still required [3] [1] [4]
J Am Acad Dermatol 65(6):1228
5.1.3 Carnitine-acylcarnitine translocase (CACT) deficiency Clinical presentation Patients with CACT deficiency (OMIM 212138) usually present in the neonatal period with severe hyperammonemia, liver failure, cardiomyopathy and respiratory distress, often with fatal outcome [23, 24, 102, 103]