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Clinical Chemistry , 2000, 46:1277-83

Strategy 6: Citizen Petitions and REMS Programs Risk Evaluation and Mitigation Strategies (REMS) are FDA-required safety programs for drugs with significant safety concerns

Its also approved to reduce the risk of major cardiovascular events (like heart attack or stroke) in adults with type 2 diabetes and established cardiovascular disease, and to reduce the risk of worsening kidney disease and cardiovascular death in adults with type 2 diabetes and chronic kidney disease

Antibiotics: conventional therapy and natural compounds with antibacterial activitya Pharmaco-toxicological screening