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However, there are IGF-I receptors on the nonparenchymal cells[89, 90] and it has been reported that IGF-I stimulates both DNA synthesis[91, 92] and the production of hepatocyte growth factor (HGF) in hepatic stellate cells in vitro [87]

Liu J, Somera-Molina KC, Hudson RL, Dubocovich ML (2013) Melatonin potentiates running wheel-induced neurogenesis in the dentate gyrus of adult C3H/HeN mice hippocampus