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According to Walker and Dhillo , Ipamorelin mimics natural pulsatile GH release without overstimulation of cortisol or prolactin (Walker & Dhillo, Nature Reviews Endocrinology )

(Journal of Clinical Endocrinology and Metabolism, 2000) reported that GHRP class compounds co-administered with GHRH produced GH release approximately two to four times greater than GHRH administration alone, establishing the practical rationale for dual-pathway activation in cjc ipamorelin blend protocols