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1 In this study, adverse events considered possibly to be caused by hydroxocobalamin were chromaturia (n=5), pink-to-red skin discoloration (n=3), increase in heart rate (n=1), and elevated blood pressure (n=1)

The most well-known of the proteins processed by NLRP3, IL-1, is one of the main pro-inflammatory cytokines upregulated by aluminum-based vaccine adjuvants [38]

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Research published in the Journal of Investigative Dermatology demonstrated KPVs direct anti-inflammatory activity independent of melanocortin receptors a key finding confirming its utility in localized inflammatory models