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Pregnant or breastfeeding women should avoid use

Although not assessed in this small study, genetic polymorphisms of metformin uptake or excretion may explain the large interindividual variations in metformin concentrations but they have not been reliably linked to metformins glucose-lowering effects [36,37,38]

It is legal as a cosmetic ingredient (listed as "Copper Tripeptide-1" on skincare labels)