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Metformin and insulin were the established treatments for T2D in youth until the recent approval by the Food and Drug Administration (FDA) of two SGLT2 inhibitors (dapagliflozin and empagliflozin) for children and adolescents above 10 years of age with T2D, for use in combination with diet and exercise

And it helps to lower their A1C," Lockman said

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In peer-reviewed trials, oral orforglipron lowered A1C by up to 2.1 percentage points (Lancet 2023) and reduced body weight by up to 14.7 % over 36 weeks (NEJM 2023)