These include anorectic effects driven by previously discussed central modulation of satiety and reward pathways and peripheral activation of vagal afferents, delayed gastric emptying, anti-inflammatory properties, potential impact on energy expenditure and the ability to reduce ghrelin levels, which are inherently elevated in PWS ( 2 to 11.3 kg/m 2 ( 2 in 10/14 cases, and an HbA1c improvement in 19/23 cases, without reported serious side effects ( Semaglutide at a dose of 2.4 mg weekly is the first weekly long-acting GLP-1 RA approved for non-syndromic obesity treatment with a mean weight change of 14.9% in individuals with obesity without diabetes ( Our case series presents the long-term efficacy and safety of semaglutide treatment in patients with PWS without diabetes as well as semaglutide efficacy and safety in PWS previously treated with metabolic surgery

Clinical Trial Results: Studies demonstrated significant reduction in visceral adipose tissue (VAT), improvements in trunk fat, effects on lipid profiles, and maintenance of effects with continued treatment (reversible upon discontinuation)
B12 injections may also be useful for those with gastrointestinal issues, older adults, vegans, vegetarians, and people with underlying health conditions that can restrict vitamin B12 absorption
Injuries that seem to take forever to heal
Fat shaming acts as a form of social control, pressuring peopleespecially womento conform