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The timepoints usedweek 52 (ONeil and STEP 5), week 56 (SCALE Obesity and Prediabetes), week 68 (STEP 1 and STEP 8) and week 72 (SURMOUNT-1)were considered broadly comparable, as the treatments were designed to reach full efficacy in this timeframe, and given the plateau observed across weight reduction outcomes around week 52 [19, 36,37,38,39,40]

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