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However, malignant tumors subvert arginine metabolic homeostasis through metabolic reprogramming: for example, hepatocellular carcinoma (HCC), which lacks the ability to synthesize arginine on its own, significantly enhances the uptake efficiency by up-regulating arginine transport proteins (e.g., SLC6A14 and CAT-1) and inhibits the conversion of arginine to polyamines, resulting in the accumulation of high concentrations of arginine in the tumor microenvironment(Mossmann et al

It is often studied in models focused on melanocyte response, appetite-related signaling, and other mechanisms linked to melanocortin receptor activation

12 Lower leptin levels are associated with a higher risk of weight gain over 2 years in healthy young adults, 29 whereas an increase in soluble leptin receptors has been associated with leptin resistance

doi: 10.1002/ana.21600

Kuscuoglu D, Janciauskiene S, Hamesch K, Haybaeck J, Trautwein C, Strnad P