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By inducing the receptor LGR4/5 to bind to Znrf3/Rnf43, R-Spondin, the negative feedback regulator of Wnt, removes the two E3 transmembrane ligases from the membrane, thus weakening the ubiquitination of Frizzled and significantly increasing the transmission of Wnt/-catenin signals

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doi: 10.1007/s00011-003-1212-6

Cook GC, Sherlock S

Brandon Vaughn 500 500 Brandon Vaughn Brandon Vaughn2025-01-04 14:24:392025-01-04 14:24:39Peptide Therapy: For ACL Rehab Ive compiled all the Q&As from Peptides 101, along with common questions from DMs, texts, and emails, into one convenient resource