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Using measurements of the pyruvate/lactate, it was found that the brain cytoplasmic [NAD + ]/[NADH] underwent a reductive redox shift in C57BL/6J mice with aging but an oxidizing redox shift in C57BL/6N mice and humans with aging

However, high-dose vitamin C can cause significant local tissue irritation if it leaks outside the vein, so the distinction still matters

Oral glutathione is used to treat infertility and many other conditions

Curr Pharm Des 10:24632475 Ballatori N, Krance SM, Notenboom S, Shi S, Tieu K, Hammond CL (2009) Glutathione dysregulation and the etiology and progression of human diseases

doi: 10.1016/j.phymed.2017.08.026