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Levodopa substitution is still the most effective approach to treat PD motor symptoms, but standard oral drug delivery is associated with plasma level oscillations that give rise to the development of motor fluctuations and dyskinesias

Conversely, the methanol fruit peel extract showed no toxicity in mice even at a dose of 5,000 mg/kg

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Chembiochem 17 CostineanS.ZanesiN.PekarskyY.TiliE.VoliniaS.HeeremaN.et al (2006)