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Be cautious with: Crash diets and very low-calorie plans Aggressive fasting if you are not supervised Highly restrictive plans that cut major food groups without a medical reason If you have diabetes, kidney disease, or take insulin/sulfonylureas, get clinician input before big changes

Ipamorelin is a selective ghrelin receptor agonist that enhances this effect by stimulating growth hormone release without elevating cortisol or prolactin

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References: Matheson EM, et al