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The decision to prescribe these medications should weigh the substantial metabolic benefits against individual gallbladder risk, recognizing that for most patients, the cardiovascular and glycemic advantages outweigh the relatively modest absolute risk increase

However, GLP-2 can neither improve the bone strength of the femoral shaft or lumbar vertebrae nor improve the bone microstructure, and it does not provide a real beneficial effect in improving bone strength in the brittle-bone mouse model

Patients with type 2 diabetes should have regular cardiovascular risk assessment, and any new cardiac symptoms should prompt thorough evaluation

Critical role of the cAMP-PKA pathway in hyperglycemia-induced epigenetic activation of fibrogenic program in the kidney

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