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Research suggests these peptides may support tendon, ligament, and soft-tissue recovery , which has led to interest in experimental models focused on musculoskeletal repair and rehabilitation pathways

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10.1074/jbc.M211558200 J

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For instance, in mouse embryonic stem cells, targeted disruption of glucose-6-phosphate dehydrogenase, which is the rate-limiting enzyme in the pentose phosphate pathway, the predominant metabolic pathway for the generation of NADPH (a cofactor of GR), renders cells extremely sensitive to H 2 O 2 -induced cell death 34