doi: 10.1053/j.ajkd.2008.03.008 28 BertocchioJPWarnockDGJaisserF
3), and increased expression level of Bax (Fig
Currently, sulfated phosphatidyl-ethanolamine hydroperoxide (SAPE-OOH) on the surface of ferroptotic cells is recognized as an eat-me signal, facilitating interaction with Toll-like receptor 2 (TLR2) on macrophages (129)
This ongoing oxidative stress leaves endothelial cells (the lining of blood vessels) highly vulnerable to ongoing damage, contributing to the micro-clotting and "immunothrombosis" frequently observed in Long Haulers
Similarly, DSePA, another interesting organoselenium compound, has shown potent efficacy as a lung-specific radiomitigator through inducing the expressions rather than mimicking the activities of seleno-GPxs, thus warranting future clinical studies [61, 62]