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Understanding these mechanisms helps explain why careful dose titration and dietary modifications may be particularly important for those who have undergone cholecystectomy

American Journal of Physiology - Gastrointestinal and Liver Physiology, 304 (11), G1038-G1043

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Additionally, IL-6, through the JAK-STAT3 pathway, increases the phosphorylation of TRPV1 in dorsal root ganglion (DRG) neurons, 78 inducing visceral pain after gastrointestinal cytokine stimulation