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IL-33 induces the production of profibrotic cytokines by regulatory T cells and promotes fibrogenesis [159,160,161,162]

Freezing is equally damaging and immediately renders the medication unusable

A surrogate endpoint may reduce the duration length and cost of clinical trials and be a better indicator of drug efficacy with hematological indices better served as secondary endpoints

DiSilvestro RA, Joseph E, Zhao S, Bomser J

Neuroinflammation disrupts neurotransmitter systems such as glutamate and dopamine, contributing to symptoms like anhedonia and impairing motivational circuits, which are classically involved in depressive disorders [81]