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Due to trial shenanigans in Russia and Georgia (possible inclusion of ineligible patients, intervention groups not even receiving spironolactone, and uncertain outcome ascertainment) nicely detailed here (Pfeffer and Pitt, NEJM Evidence 2022), the official, hard EBM line remained that spironolactone does not work in HFpEF

In the meantime, Novo Nordisk advises stopping Wegovy at least two months before a planned pregnancy to allow for what is known as a washout period the recommended length of time it takes for a given drug to clear a patients body

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Frequently Asked Questions Are compounded GLP-1 medications FDA approved