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Without direct tissue quantification, it is unknown if the CNS exposure was high, or if the large systemic dose simply compensated for low anatomical delivery efficiency across the nasal mucosa

Novo Nordisk said that about 25% of participants in the trial who took the higher dose of Wegovy (7.2 mg of semaglutide) lost about 27.7% of their body weight 72 weeks after beginning Wegovy

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