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Due to poor solubility of some chemotherapy drugs in water as well as lack of specificity in drug localization into a tumor, they often have drastic side effects on non-targeted tissues

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These reports remain unvalidated by large-scale studies and may reflect a range of confounding factors rather than a direct pharmacological effect of semaglutide

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Meakin, P.J., et al., Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes but not with insulin resistance