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Exenatide extended-release (Bydureon/BCise) carries a boxed warning regarding thyroid C-cell tumors based on rodent studies and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

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NO is a potent vasodilator, and low levels of intracellular ROS play a crucial role in normal redox signaling that helps to maintain vascular function and integrity under physiological conditions (122)

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