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Mateus J, Grifoni A, Tarke A, Sidney J, Ramirez SI, Dan JM, et al

263 Moreover, the possibility of surface decoration of targeting ligands could further promote their penetration of biological barriers

However, there are some inconsistencies in the literature, which may be attributed to differences in the disease severity, age, gender, comorbidity, the investigated brain regions, the status and duration of medications in subjects

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Researchers hypothesized that, while the increased thyroid hormone increased carnitine synthesis, it also accelerated mitochondrial fatty acid oxidation (similar to what was seen to happen in a hyperthyroid state), which reduced carnitine levels