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This is a life-threatening clinical-dermatological emergency that presents with a variety of symptoms and signs, including skin rash (especially of the exanthema type), which may be accompanied by fever, lymphadenomegaly, hepatitis, hematological (especially atypical lymphocytes and eosinophilia), renal, cardiac, pulmonary and pancreatic changes.1 The term DRESS was initially proposed by Bocquet et al., in 1996, in a review article on the drug hypersensitivity syndrome, which had been previously described under several different terms or synonymies, such as dapsone syndrome, anticonvulsant hypersensitivity syndrome, hydantoin syndrome, and allopurinol hypersensitivity syndrome, depending on the pharmacological agent involved, throughout the 20th century.2 The first case description compatible with DRESS was reported by Myers et al., in 1937

"It was impressive to see that every dose of retatrutide resulted in clinically meaningful weight reduction for nearly all participants and people with severe obesity on the highest dose lost on average 30% of their body weight during two years." Importantly, treatment with retatrutide not only resulted in robust weight reduction, but also in clear improvements in assessed cardiometabolic health measures
doi: 10.1126/scitranslmed.3006767 192 YoonYMLeeJHYunSPHanYSYunCWLeeHJet al