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Conversely, breast cancer cells produce IL-6, which activates the JAK2/STAT3 axis, inducing TAMs to secrete TGF-1, thereby forming a positive feedback loop that ultimately facilitates malignant tumor progression [121]

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i , Inefficiently metastasizing human melanomas were transplanted subcutaneously into NSG mice and the number of melanoma cells per microlitre of blood and tumour-draining lymph were determined ( n = 4 or 5 mice per melanoma from two independent experiments)