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Rarely, immune-related inflammation of the kidneys (acute interstitial nephritis) has been reported

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The most common ones seen in studies include: Nausea Vomiting Diarrhea Constipation Abdominal discomfort Less common or study-observed effects have included: Transient increases in resting heart rate Mild liver-enzyme changes Injection-site reactions Questions Researchers Are Still Studying Long-term cardiovascular outcomes The balance between fat loss and lean-mass loss Long-term metabolic maintenance Ideal dosing strategies How retatrutide performs across different health backgrounds Because research is ongoing, these areas will continue to be refined over time