J Med Chem 58:73707380 Gotfredsen CF, Molck AM, Thorup I et al (2014) The human GLP-1 analogs liraglutide and semaglutide: absence of histopathological effects on the pancreas in nonhuman primates
Prog Neurobiol
Enzymes of serine metabolism in normal, developing and neoplastic rat tissues
Ian Douglas, PhD, BSc, professor of pharmacoepidemiology at the London School of Hygiene & Tropical Medicine, who was also not involved in the study, pointed out: The time at which someone starts a treatment for obesity can itself be correlated with mental health difficulties, and the effects of the medication on weight, whether this is a dramatic reduction in weight, or a disappointing lack of weight reduction, can also trigger changes in mental health. If we want to know whether GLP-1 agonists cause changes in mental health status, either through their direct pharmacological action or indirectly through their action on weight, we ideally need studies that compare people treated with GLP-1 agonists with similar people not receiving them to see if there are differences in their risk of mental health outcomes. Ian Douglas, PhD, BSc Of the NIH study, Douglas said, I wouldnt go so far as to say GLP-1 agonists prevent mental health problems based on these findings, but the results are certainly not consistent with a harm. Douglas questioned the methodology used in the new study, saying that individual spontaneous reports of suspected adverse drug reactions [] such as those used in the new study are not an appropriate resource in which to test this hypothesis about GLP-1 agonists. Ali expressed a similar concern
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