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doi: 10.1210/clinem/dgaa903 79

Further, targeted metabolomics and isotope tracing experiments uncovered GGCT as a metabolic orchestrator to prioritize Gln to GSH flux for antioxidant defense, while activating glucose (Glc)-fueled anaplerosis to replenish TCA intermediates to fuel proliferation

Il tratto gastrointestinale la nostra prima difesa contro tossine e radicali liberi: qui il glutatione ridotto agisce con un effetto "paracrino", venendo utilizzato direttamente dalle cellule della mucosa intestinale per neutralizzare lo stress ossidativo locale

Yan F, Wei H, Ding Y, Li W, Chen L, Ding C, et al

The nuclear receptor ppar gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses cns autoimmunity