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L-arginine, administered through renal medullary interstitial infusion 86 , intravenous infusion 117,118 , intraperitoneal injections 87 or oral supplementation 87,119,120 , increases the generation of NO and substantially attenuates hypertension in SS rats

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Certainly, there is now strong evidence not only for a causal effect on gout but also for associations with metabolic syndrome and related cardiometabolic disorders 2