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For patients using insulin or sulfonylureas, proactive dose reduction of these medications should be considered before tirzepatide escalation to mitigate hypoglycemia risk, with increased glucose monitoring during the transition

Rushing the insertion increases pain and reduces control over depth

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EMT is a multi-step process in which epithelial cells lose their characteristic traits and gain mesenchymal features, including the loss of cell junctions and apicobasal polarity [33]