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The review also notes that GLP-1 medicines reduce complications in conditions such as obstructive sleep apnea (OSA), expanding their cardiometabolic relevance

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(2026) Exendin-4 enhances GLP-1 signaling and reduces anxiety-like behaviors in male heroin withdrawal mice

found that GLP-1 RAs are associated with an increased risk of gallbladder and biliary diseases (including cholelithiasis and cholecystitis), particularly at higher doses, longer treatment durations, and when used for weight loss [129]