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Variation in GLP1R (the GLP-1 receptor), FTO , MC4R , and TCF7L2 shapes the appetite, energy-balance, and glucose biology tirzepatide engages

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Although appropriate treatment goals should be set for older patients with diabetes, paying attention to their individual characteristics, oral semaglutide may be an effective means of achieving these goals in older patients as a whole

The decision to continue, modify, or discontinue semaglutide should be made collaboratively, weighing the therapeutic benefits against tolerability concerns and individual patient circumstances

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