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Hypoxia then stabilizes HIF-1 and upregulates REST, which suppresses GCLM/GPX4 expression and enhances ACSL4-dependent lipid peroxidationdirectly amplifying ferroptosiswhile also promoting the release of hypoxic extracellular vesicles (EVs) that propagate tubular ferroptosis in a paracrine manner
About this article Cite this article Zhang, J., Quan, C., Wang, C
therefore, improving lifestyle, reducing smoking, controlling weight, and providing psychological health guidance are treatment methods that target the specific pathogenesis of RA
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