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Any decline in redox enzymes may increase free radical generation with subsequent induction of lipid peroxidation, protein oxidation, and DNA/RNA degradation 557,558,559
According to the UK product information, no dose adjustment is required for patients with renal or hepatic impairment, or based on age or body weight, as these factors have no clinically relevant effect on semaglutide's pharmacokinetics
Although its currently approved for type 2 diabetes, its potential for weight loss is generating significant interest
doi: 10.1016/S0140-6736(20)30367-6 7
