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The proposed direct vascular mechanisms, supported by preclinical and clinical data, include the following: Endothelial protection: GLP-1 receptor agonists promote nitric oxide production, vasodilation, and angiogenesis while inhibiting oxidative stress in vascular endothelial cells Plaque stabilization: Reduced matrix metalloproteinase activity prevents fibrous cap degradation
In Phase 3 clinical trials completed in December 2025, retatrutide produced an average body weight reduction of 28.7% at the highest dose over 68 weeks
Who Should Be Especially Cautious
Compounded semaglutide is typically safe for most people, too, but there are no clinical trials backing this up
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