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These signs can include the drug changing color

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Similarly, in vitro cytotoxicity assays performed in MCF-7 (breast cancer cell line) and T98G (GBM cell line) showed a significantly reduced cell viability with HA-FA/5-FU-MSN and CNCH-DA/5-FU-MSN, with HA-FA showing the most pronounced effects

Application of the vant Hoff equation to the Best values gives H sln = 28.7 kJ mo1 -1 and C p,s1n = 73 JK -1 mo1 -1 for the dissolution of water in hexane