In Japan, ALS patients received B12 shots of 25,000-50,000mcg (each shot equal to 25-50 pernicious anemia shots all at once), at first daily and then twice a week
Its defining scientific characteristic, selective stimulation of lipolysis through the beta-3 adrenergic receptor pathway without IGF-1 elevation or growth hormone receptor binding, is identical between both formats
Not all B12 that you eat or take in supplements is absorbed and research indicates that to achieve a sufficient daily dose of B12, you should take at least five to 50 micrograms daily or 1,000 to 2,000 micrograms weekly (Del Bo et al., 2019
They provide detailed product information with its purity levels and suggested usage
(Nature Communications) demonstrated that selective NNMT inhibition in diet-induced obese mice produced significant reductions in fat mass and improvements in insulin sensitivity without caloric restriction