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Results of bariatric surgery in 24 children/adolescents PWS compared to 72 non-PWS subjects matched for age, gender and BMI, undergoing a laparoscopic sleeve gastrectomy, have recently been published [107]

Premature adrenarche in Prader-Willi syndrome is associated with accelerated pre-pubertal growth and advanced bone age

Microwaving a peptide solution will instantly destroy it with heat

So while the direction of the findings is encouraging, particularly for blood sugar, it is fair to say the berberine evidence is not as settled, and long-term data in particular is limited

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