N Engl J Med 345(12):861869 Moorhead JF, Brunton C, Varghese Z (1997) Glomerular atherosclerosis
Although the SAVOR and EXAMINE studies were delineated to verify cardiovascular safety of two DPP-4i, namely saxagliptin and alogliptin, respectively, both are considered to be the first controlled clinical trials to address the effect of GLP-1 system on CVD
10.1053/j.gastro.2005.02.033 Gastroenterology 152 SimonM
Patients taking tirzepatide are advised to switch to a non-oral contraceptive or add a barrier method of contraception for four weeks after first taking the medicine and for four weeks after each increase in the dose. In June this year, the UK Medicines and Healthcare products Regulatory Agency (MHRA) issued a warning to women taking weight loss drugs, urging them to use effective contraception while on the drugs, after dozens of reports of unintentional pregnancies
[4] While common, it is important to note that these events are generally mildtomoderate, and they are also often transient, occurring most frequently during or shortly after dose escalation