Kidney-gut axis in chronic kidney disease: therapeutic perspectives from microbiota modulation and nutrition
Baio A, Sousa F, Oliveira AV, Oliveira C, Sarmento B (2020) Effective intracellular delivery of bevacizumab via PEGylated polymeric nanoparticles targeting the CD44v6 receptor in colon cancer cells
This review highlights the prevalence, molecular mechanisms and combating approaches of underlying risk conditions by managing endothelial dysfunction, hypertension, and platelet hyperactivity/prothrombotic state with bioactive compounds like polyphenols, small molecules like miRNA, and gene therapy
Additionally, erythrocytes utilize the reactions of the PPP to generate large amounts of NADPH used in the reduction of glutathione (see below)
Glutathione is also known to promote long-term eye health , namely of the retina, lens, and cornea