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GA was found to improve several markers of renal function, oxidative stress, and inflammation, including serum urea, uric acid, creatinine, phosphorus, malondialdehyde, TAC, and C-reactive protein ( GA is also recognized as an effective prebiotic agent that supports the growth of the gastrointestinal microbiome (Zhao et al., 2023), it is plausible that GA favorably enhanced the metabolism and absorption of melatonin and betaine when added to the combination