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Anthracyclines (as well as trastuzumab) are characterized by dose-dependent cardiomyopathy, arrhythmias, and left ventricular dysfunction (216), with some tyrosine kinase inhibitors associated to QT prolongation or increased blood pressure

Potential interactions with drugs metabolized by methyltransferases should be considered

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FDA concluded that available studies were too limited to characterise genotoxic or carcinogenic potential adequately