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For Long-Term Maintenance On the other hand, if your patient is looking for a long-term solution to support gradual weight loss and overall health, oral supplements are a solid choice

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Switching to a compounded formulation that includes B12 alongside the semaglutide addresses the deficiency directly, and fatigue improves by week six

Last reviewed: May 30, 2026 Last updated: May 30, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations