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The titration exists to reduce side effects while your body adapts

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Berney M, Berney-Meyer L, Wong KW, Chen B, Chen M, Kim J, Wang J, Harris D, Parkhill J, Chan J, Wang F

in the context of a balanced triple agonist, its classical effect on hepatic glucose production is offset by the simultaneous GLP-1R/GIPR insulinotropic action, while the metabolic effects that peptide designers actually want from GCGR are retained: increased energy expenditure via brown-adipose thermogenesis and skeletal-muscle oxidation, adipose lipolysis with free-fatty-acid release for beta-oxidation, and hepatic fatty-acid oxidation that clears triglyceride from the liver 27

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