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The region encompassing W297 ECL2 -N300 ECL2 was identified as essential in rat GLP-1R and hGLP-1R by double-Ala scanning, whereas the residues spanning S301 ECL2 -N304 ECL2 did not alter GLP-1 pharmacology (Mann et al., 2010a

Lin, Nguyen, Russell and Pollard, "Colony-Stimulating Factor 1 Promotes Progression of Mammary Tumors to Malignancy", J

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Diabetes Obes Metab 15: 417-426, 2013

Our findings build on previous research showing high discontinuation rates, particularly among individuals using GLP-1 RAs for weight management ( 10 ), and provide new insights into how and why these medications are stopped in real-world clinical settings