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It does this by activating the GH axis, which leads to a downstream increase in systemic growth hormone levels

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By contrast, numerous studies have shown that intestine-specific FXR-deficiency and pharmacological inhibition of intestinal FXR protect mice from HFD-induced obesity, insulin resistance and NAFLD 21,22,23,24 , these beneficial effects being mediated, at least in part, via decreased intestinal ceramide synthesis and secretion 41